abstract：:Cancer metabolism has been extensively investigated by various tools, and the fact of diverse metabolic reprogramming in cancer cells has been gradually unveiled. In this review, we discuss some contributions in cancer metabolism by general proteomic analysis and post-translational modification analysis using mass spe...

journal_title：Cancer letters

authors： Zhou W,Liotta LA,Petricoin EF

更新日期：2015-01-28 00:00:00

abstract：:Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-...

journal_title：Cancer letters

authors： Morgan WF,Sowa MB

更新日期：2015-01-01 00:00:00

abstract：:An increase in the levels of oxidation is a universal feature of genomic DNA of irradiated or aged or even malignant cells. In case of apoptotic death of stressed cells, oxidized DNA can be released in circulation (cfDNA). According to the results of the studies performed in vitro by our group and other researchers, t...

journal_title：Cancer letters

authors： Glebova K,Veiko N,Kostyuk S,Izhevskaya V,Baranova A

更新日期：2015-01-01 00:00:00

abstract：:The role of mesothelial cells in the intraperitoneal spread of ovarian cancer is still elusive. In particular, it is unclear whether these cells constitute a passive barrier preventing cancer cell progression or perhaps act as an active promoter of this process. In this report we show that omental human peritoneal mes...

journal_title：Cancer letters

authors： Mikuła-Pietrasik J,Sosińska P,Kucińska M,Murias M,Maksin K,Malińska A,Ziółkowska A,Piotrowska H,Woźniak A,Książek K

更新日期：2014-12-28 00:00:00

abstract：:Pancreatic cancer is a malignant disease without efficient treatment. Improved treatments are urgently needed to enhance or replace chemotherapy. Here we used a small molecular compound LB-100 to assess the effect of pharmacological inhibition of protein phosphatase 2A (PP2A) in combination with doxorubicin on the pro...

journal_title：Cancer letters

authors： Bai X,Zhi X,Zhang Q,Liang F,Chen W,Liang C,Hu Q,Sun X,Zhuang Z,Liang T

更新日期：2014-12-28 00:00:00

abstract：:Application of functional imaging to radiotherapy (RT) is a rapidly expanding field with the development of new modalities and techniques. Functional imaging of PET in conjunction with RT provides new avenues towards the clinical application of dose painting - a new RT strategy delivering optimized dose redistribution...

journal_title：Cancer letters

authors： Shi X,Meng X,Sun X,Xing L,Yu J

更新日期：2014-12-28 00:00:00

abstract：:Vaccines containing synthetic peptides derived from tumor-associated antigens (TAA) can elicit potent cytotoxic T lymphocyte (CTL) response if they are formulated in an optimal vaccine delivery system. The aim of this study was to develop a simple and effective lipid-based vaccine delivery system using P5 HER2/neu-der...

journal_title：Cancer letters

authors： Shariat S,Badiee A,Jalali SA,Mansourian M,Yazdani M,Mortazavi SA,Jaafari MR

更新日期：2014-12-01 00:00:00

abstract：:Sorafenib is the approved systemic drug of choice for advanced hepatocellular carcinoma (HCC), but has demonstrated limited benefits because of drug resistance. 2-Methoxyestradiol (2ME2) has been shown to be a promising anticancer drug against various types of cancers and acts by dysregulating hypoxia-inducible factor...

journal_title：Cancer letters

authors： Ma L,Li G,Zhu H,Dong X,Zhao D,Jiang X,Li J,Qiao H,Ni S,Sun X

更新日期：2014-12-01 00:00:00

abstract：:Mutations in the APC (adenomatous polyposis coli) gene, which encodes a multi-functional protein with a well-defined role in the canonical Wnt pathway, underlie familial adenomatous polypsosis, a rare, inherited form of colorectal cancer (CRC) and contribute to the majority of sporadic CRCs. However, not all sporadic ...

journal_title：Cancer letters

authors： Mazzoni SM,Fearon ER

更新日期：2014-12-01 00:00:00

abstract：:Acute myeloid leukemia (AML) cells in vivo are constantly exposed to lymphangiogenic cytokines such as VEGF-C. However, it is poorly understood how the VEGF-C signaling modulates the immune functions in the tumor microenvironment. We have previously reported that natural killer (NK) cells in AML patients strongly upre...

journal_title：Cancer letters

authors： Lee JY,Park S,Min WS,Kim HJ

更新日期：2014-11-28 00:00:00

abstract：:Pancreatic cancer is an aggressive malignancy and unresponsive to conventional chemotherapies. Here, the anti-inflammatory and anti-tumor effects of embelin on pancreatic cancer were investigated. Embelin significantly attenuated cells invasion, proliferation and induced apoptosis through inhibition of STAT3 and activ...

journal_title：Cancer letters

authors： Peng M,Huang B,Zhang Q,Fu S,Wang D,Cheng X,Wu X,Xue Z,Zhang L,Zhang D,Da Y,Dai Y,Yang Q,Yao Z,Qiao L,Zhang R

更新日期：2014-11-28 00:00:00

abstract：:We previously reported that β6 integrin played an important role in the progression of colon cancer. In this study, we demonstrated that β6 integrin induced the expression of MMP-3/MMP-9 and the invasion of colon cancer cells. Moreover, that function was abolished by the inhibition of ERK/MAPK pathways or knockdown of...

journal_title：Cancer letters

authors： Gao H,Peng C,Liang B,Shahbaz M,Liu S,Wang B,Sun Q,Niu Z,Niu W,Liu E,Wang J,Lin P,Wang J,Niu J

更新日期：2014-11-28 00:00:00

abstract：:Activation of the BTLA-HVEM co-inhibitory signaling pathway impairs antitumor immunity. Our previous study demonstrated that the extracellular domain of murine BTLA (the soluble form of BTLA) can facilitate HSP70 vaccine-triggered antitumor immunity by blocking BTLA-HVEM interactions in a murine TC-1 non-metastatic tu...

journal_title：Cancer letters

authors： Han L,Wang W,Lu J,Kong F,Ma G,Zhu Y,Zhao D,Zhu J,Shuai W,Zhou Q,Chen P,Ye L,Tao J,Ahmad S,Li F,Sun J

更新日期：2014-11-28 00:00:00

abstract：:Given its contribution to malignant phenotypes of cancer, tumor hypoxia has been considered as a potential therapeutic problem. In the stressful microenvironment condition, hypoxia inducible factor 1 (HIF1) is well known to mediate the transcriptional adaptation of cells to hypoxia and acts as a central player for the...

journal_title：Cancer letters

authors： Kim YH,Yoo KC,Cui YH,Uddin N,Lim EJ,Kim MJ,Nam SY,Kim IG,Suh Y,Lee SJ

更新日期：2014-11-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) are the predominant cell type in tumor microenvironment (TM) and featured with the distinct energy metabolism reprogramming (EMR) phenotype caused by many factors such as hypoxia and growth factors. The EMR of CAFs plays a key role in biological behaviors of cancer cells including ...

journal_title：Cancer letters

authors： Tang S,Yang L,Tang X,Liu M

更新日期：2014-10-28 00:00:00

abstract：:The tumor microenvironment (TME) of lung cancer has been documented to play an important role in participating in tumor disease progression. As the precursor of most stroma in TME, mesenchymal stem cells (MSCs) draw great attention since evidence has suggested that MSCs derived from lung cancer patients present a diff...

journal_title：Cancer letters

authors： Liu R,Wei S,Chen J,Xu S

更新日期：2014-10-28 00:00:00

abstract：:The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid -directed processes. Recently, this protein has emerged as an important player in carcinogenesis process. HnRNP K is overexpressed in several hum...

journal_title：Cancer letters

authors： Barboro P,Ferrari N,Balbi C

更新日期：2014-10-01 00:00:00

abstract：:One of the frontiers in cancer personalized-medicine aims at glycosylation. Cells are covered with a dense sugar coat of glycolipids, glycoproteins and free glycans. In cancer, the characteristic cell surface glycosylation is frequently transformed due to altered expression of glycan-modifying enzymes. This often lead...

journal_title：Cancer letters

authors： Padler-Karavani V

更新日期：2014-09-28 00:00:00

abstract：:The traditional "one treatment fits all" paradigm disregards the heterogeneity between cancer patients, and within a particular tumor, thus limit the success of common treatments. Moreover, current treatment lacks specificity and therefore most of the anticancer drugs induce severe adverse effects. Personalized medici...

journal_title：Cancer letters

authors： Rosenblum D,Peer D

更新日期：2014-09-28 00:00:00

abstract：:Estrogens are important for the development and growth of estrogen receptor (ER)-positive breast cancer, for which anti-estrogen therapy is one of the most effective treatments. However, its efficacy can be limited by either de novo or acquired resistance. Aromatase is a key enzyme for the biosynthesis of estrogens, a...

journal_title：Cancer letters

authors： Phuong NT,Lim SC,Kim YM,Kang KW

更新日期：2014-08-28 00:00:00

abstract：:The incidence of breast cancer has increased rapidly in recent years and has now become the most common cancer in women in major cities of China. Here, we reviewed the history and progress of breast cancer research in China, including achievements that Chinese scientists have made in basic, translational and clinical ...

journal_title：Cancer letters

authors： Hong W,Dong E

更新日期：2014-08-28 00:00:00

abstract：:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that facilitates the maturation of a wide range of proteins, and it has been recognized as a crucial facilitator of oncogene addiction and cancer cell survival. Although HSP90 function is regulated by a variety of post-translational modifications,...

journal_title：Cancer letters

authors： Hamamoto R,Toyokawa G,Nakakido M,Ueda K,Nakamura Y

更新日期：2014-08-28 00:00:00

abstract：:Toxicity reduction of cisplatin is necessary for improved treatment of cancer. Here we have demonstrated the synergistic growth-inhibitory effect of cisplatin on cervical cancer cells in-combination with a nontoxic herbal carbazole alkaloid, mahanine. Mahanine enhanced cisplatin-induced apoptosis and reduced its effec...

journal_title：Cancer letters

authors： Das R,Bhattacharya K,Samanta SK,Pal BC,Mandal C

更新日期：2014-08-28 00:00:00

abstract：:TGF-β signaling plays an important role in breast cancer progression and metastasis. Epithelial-mesenchymal transition (EMT) is an important step in the progression of solid tumors to metastatic disease. We previously reported that IN-1130, a novel transforming growth factor-β type I receptor kinase (ALK5) inhibitor, ...

journal_title：Cancer letters

authors： Park CY,Min KN,Son JY,Park SY,Nam JS,Kim DK,Sheen YY

更新日期：2014-08-28 00:00:00

abstract：:This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HR...

journal_title：Cancer letters

authors： Martin LM,Marples B,Lynch TH,Hollywood D,Marignol L

更新日期：2014-07-10 00:00:00

abstract：:To identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively toxic toward AML cell lines and primary AML patient samples with no effect toward normal hematopoiet...

journal_title：Cancer letters

authors： Angka L,Lee EA,Rota SG,Hanlon T,Sukhai M,Minden M,McMillan EM,Quadrilatero J,Spagnuolo PA

更新日期：2014-06-28 00:00:00

abstract：:Multi-drug resistance (MDR) has become the largest obstacle to the success of cancer chemotherapies. The mechanisms of MDR and the approaches to test MDR have been discovered, yet not fully understood. This review covers the in vivo and in vitro approaches for the detection of MDR in the laboratory and the mechanisms ...

journal_title：Cancer letters

authors： Wu Q,Yang Z,Nie Y,Shi Y,Fan D

更新日期：2014-06-01 00:00:00

abstract：:Pregnane X receptor (PXR) regulates cell proliferation and carcinogenesis in female reproductive tissue. We showed that PXR was expressed in cervical cells and tissue samples. PXR were lower or greatly diminished in cancer tissues compared to normal control. Functionally, activation of human PXR by rifampicin or ectop...

journal_title：Cancer letters

authors： Niu Y,Wang Z,Huang H,Zhong S,Cai W,Xie Y,Shi G

更新日期：2014-05-28 00:00:00

abstract：:The chimeric transcripts described in endometrial stromal sarcomas (ESS) are JAZF1/SUZ12, YWHAE/FAM22, ZC3H7/BCOR, MBTD1/CXorf67, and recombinations of PHF1 with JAZF1, EPC1, and MEAF6. The MEAF6/PHF1 fusion had hitherto been identified in only one tumor. We present two more ESS with MEAF6/PHF1 detected by transcripto...

journal_title：Cancer letters

authors： Micci F,Gorunova L,Gatius S,Matias-Guiu X,Davidson B,Heim S,Panagopoulos I

更新日期：2014-05-28 00:00:00

abstract：:Highly active antiretroviral therapy (HAART) changed the natural history of pediatric HIV infection. This review focuses on trends of HIV-associated cancers in childhood in the HAART era and analyses potential pathogenetic mechanisms. HAART reduced AIDS-defined-malignancies (ADM), but incidence of several non-ADM is i...

journal_title：Cancer letters

authors： Chiappini E,Berti E,Gianesin K,Petrara MR,Galli L,Giaquinto C,de Martino M,De Rossi A

更新日期：2014-05-28 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers. Their mechanisms in anti-tumorigenesis are not fully understood, but both cyclooxygenase (COX)-dependent and -independent pathways play a r...

journal_title：Cancer letters

authors： Liggett JL,Zhang X,Eling TE,Baek SJ

更新日期：2014-05-01 00:00:00

abstract：:Oleanolic acid (OA, 3β-hydroxyolean-12-en-28-oic acid) is a ubiquitous pentacyclic multifunctional triterpenoid, widely found in several dietary and medicinal plants. Natural and synthetic OA derivatives can modulate multiple signaling pathways including nuclear factor-κB, AKT, signal transducer and activator of trans...

journal_title：Cancer letters

authors： Shanmugam MK,Dai X,Kumar AP,Tan BK,Sethi G,Bishayee A

更新日期：2014-05-01 00:00:00

abstract：:Multiple studies have shown that cancer patients produce detectable autoantibodies against certain tumor-associated antigens, which might be promising blood biomarkers for early detection of colorectal cancer (CRC). We aimed to provide an overview of published studies on blood autoantibody markers for early detection ...

journal_title：Cancer letters

authors： Chen H,Werner S,Tao S,Zörnig I,Brenner H

更新日期：2014-05-01 00:00:00

abstract：:Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In...

journal_title：Cancer letters

authors： Hu X,Liu Y,Qin C,Pan Z,Luo J,Yu A,Cheng Z

更新日期：2014-04-28 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most malignant form of central nervous system tumor, and current therapies are largely ineffective at treating the cancer. Developing a more complete understanding of the mechanisms controlling the tumor is important in order to explore new possible treatment options. It is specula...

journal_title：Cancer letters

authors： Haley EM,Kim Y

更新日期：2014-04-28 00:00:00

abstract：:Far-infrared (FIR) radiation is known to lessen the risk of angiogenesis-related diseases including cancer. Because deficiency of secretory clusterin (sCLU) has been reported to inhibit angiogenesis of endothelial cells (EC), we investigated using human umbilical vein EC (HUVEC) whether sCLU mediates the inhibitory ef...

journal_title：Cancer letters

authors： Hwang S,Lee DH,Lee IK,Park YM,Jo I

更新日期：2014-04-28 00:00:00

abstract：:Cancers of the gastrointestinal (GI) tract continue to represent a major health problem, despite progress in therapy. Gut microbiota is a key element related to the genesis of GI cancers, countless papers addressing this burning issue across the world. We provide an updated knowledge of the involvement of gut microbio...

journal_title：Cancer letters

authors： Serban DE

更新日期：2014-04-10 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal types of cancer with poor prognosis. Despite extensive efforts, the current treatment methods have limited success. Therefore, novel therapeutic approaches are required. The pancreatic tumor microenvironment is rich in growth factors and inflammato...

journal_title：Cancer letters

authors： Roshani R,McCarthy F,Hagemann T

更新日期：2014-04-10 00:00:00

abstract：:Growing evidence from epidemiologic and preclinical studies suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, colorectal cancer, and hepatocellular carcinoma. However, there is also evidence indicating the absence of...

journal_title：Cancer letters

authors： Sahin IH,Hassan MM,Garrett CR

更新日期：2014-04-10 00:00:00

abstract：:Despite recent improvements in chemotherapy and surgery, the problem of non-response osteosarcoma to chemotherapy remains, and is a parameter that is critical for prognosis. The present work investigated the therapeutic value of NVP-BEZ235, a dual class I PI3K/mTOR inhibitor. NVP-BEZ235 inhibited osteosarcoma cell pro...

journal_title：Cancer letters

authors： Gobin B,Battaglia S,Lanel R,Chesneau J,Amiaud J,Rédini F,Ory B,Heymann D

更新日期：2014-03-28 00:00:00